Aniracetam: An Anxiolytic for those who like to keep their wits about them

Ampakines are so effective at increasing our awareness of the world around us that DARPA has investigated them for military applications.

You will feel this smart drug ‘switch on’ in your brain after 5–10 minutes. It is a positive influence on stress, memory and creativity. It’s mechanism of action revolves around the AMPA Receptor which defines many dimensions of our experience of reality.

Got anxiety? Aniracatam is chemistry’s gift the anxious and nervous, it is an anxiolytic, meaning that it replaces the physiological and psychological experience of anxiety with a sense of calm, clarity and well being. It is not a sedative so it’s unlike many ‘cures’ for anxiety it doesn’t bring you ‘down’. A 2001 Japanese study demonstrated it as highly effective in treating anxiety.
A report of on
“…dreaming quite a bit and waking up excited. All physical appetites were heightened, anxiety virtually nonexistent. It is difficult to overemphasize the novelty of that condition! Productivity was well over typical..”

What about those struggling with depression? It is also demonstrated as an effective antidepressant for aged brains in another study by the same Japanese team. This is because Aniracetam promotes dopamine and serotonin. To quote a third Japanese study:
“Aniracetam, a cognition enhancer, has been recently found to preferentially increase extracellular levels of dopamine (DA) and serotonin (5-HT) in the prefrontal cortex (PFC)…”
An American 2002 study also suggested that Ampakine drugs decrease submissive behavior:
“The present study tests the activity of nootropic drugs in a behavioral test linked to depression. This test measures the reduction of submissive behavior in a competition test…”

AMPA Receptors have a lot to do with learning and formation of long term memories. Ampakines also upregulate Brain-derived Neurotrophic factor (BDNF) which has all kinds of positive implications for the mind, including Nueroplasticity according to a 2006 Norwegian study. Aniracetam is Cholinergic, meaning that it promotes the third major neurotransmitter, Acetylcholine. Acetylcholine, is an essential chemical component of the process of creating new connections between brain cells, along with the corresponding memories, skill sets and personal development.
To quote an enthusiastic Reddit account on Aniracetam’s effects on the memory:
“I took as much as… 9g of aniracetam. I advise you to not take such high doses, unless you would like to become a super computer… Becoming a computer is not important in a world with a myriad of computer-like humans and technology. “

Anecdotally, it is reported as a stimulant of ‘collective and holistic thinking’ meaning that it’s useful for people who need to solve puzzles or pull together disparate pieces of information to find a solution. It increases blood flow to and thereby energizes the association cortex which is responsible for this inclusive form of problem solving.

AMPA Receptor modulation by Aniracatam has been investigated as an effective treatment for various nuerodegenerative conditions including Alzheimer’s disease. The health of the AMPA receptor has a lot to do with preventing and treating a host of brain conditions, to quote a 2004 UK study on Aniracetam and Piracetam:
“Data indicate that these molecules modulate glutamatergic transmission, enhance synaptic transmission, long-term potentiation (LTP) and increase neurotrophin expression. Therefore, these AMPA receptor potentiators offer an exciting new class of drugs with potential for treating (1) cognitive impairment associated with Alzheimer’s disease and schizophrenia, (2) depression, (3) slowing the progression and potentially enhancing recovery from Parkinson’s disease.”
Supplementing Aniracatam is a generally great idea for the elderly, to quote a New Zealand paper that was published in Drugs & Aging:
“Preliminary evidence of the potential benefits and good tolerability profile of aniracetam support continued evaluation of its use in patients with mild to moderate senile dementia of the Alzheimer type.”

To quote a Reddit user:
“Aniracetam straightup reminds me of a low dose of mushroom, benzo and amphetamine. I cannot believe that something like this doesn’t have any major side effects or withdrawal (so far).
Things actually started getting trippy when I was having a conversation with someone. Also, since finals are over, I should be curled up under the blanket, crying like a bitch from focalin withdrawal, drinking to wash the pain and emptiness away.
Instead, aniracetam seems to have this similar effect to focalin in that it kills boredom, laziness and gives you a certain sense of purpose. I expected the effect to be long gone after the drug is metabolized but it seems to linger on the next day.”

The drug has been studied since it was first synthesized in the 1970’s by Hoffmann-La Roche. Although you can find almost 100 studies and scientific papers specifically on Aniracatam on Pubmed, it is sometimes criticized as a smart drug for having a shortage of human studies. It is sold in Europe as prescription drug, going to by a couple of names that sound downright devilish like Draganon, Sarpul, Ampamet, Memodrin and Referan.

Cofactors: Since it promotes Acetylcholine but is not a building block of the important neurotransmitter, it’s great idea to take with an Acetylcholine precursor like Alpha GPC or a Choline supplement. It is fat soluble, so take it with fatty acids either in your diet or supplementation.

Recommended Daily

750–1500 Milligrams, high end dosage of 1–2 Grams

Side Effects

Brain toxicity and hepatoxicity are unrecorded

Other Racetams

Originally published at

Written by

Adventuring philosopher, Pompous pontificator, Writer, K-Selected Biohacker, Tantric husband, Raconteur & Smart Drug Dealer 🇺🇸

Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store