Doctors like to tell their patients that there’s no cure for Dementia or Alzheimer’s, that you just need to suffer a slow decline of your mind for decades and will be spending a small fortune on increasingly ineffective pharmaceutical drugs. Being diagnosed with a degenerative condition is not a death sentence, it can be overcome with an intentional and persistent biohacking strategy.
Piracetam — This is probably the first thing I’d recommend because it falls at the intersection of being very safe, affordable, effective and scientifically proven to improve the mind.
- It’s been used in a 20 year population study of cognitive decline in the elderly.
- Along with Ginkgo Biloba, it was identified as a promising pharmaceutical intervention in a 2018 German paper, Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer’s Disease.
- A 2018 Taiwanese meta analysis paper analyzed 235 selected studies [involving] 44,854 patients with dementia (mainly vascular dementia, Alzheimer disease, and mild cognitive impairment). It identified Piracetam and Aniracetam as an effective intervention for dementia.
It imbues a cognitive edge both in the short and the long term; usually it has an energizing effect that peps you up 40–60 minutes after dosing and improves verbal intelligence, it opens up your vocabulary. It’s a quintessential smart drug that instills a pleasantly intense focus. After several weeks or months of dosing it has a more profound effect on your long term memory — it’s frequently reported that people remember obscure little things from their distant past. You’ll find yourself remembering a foreign language that you learned in high school as opposed to forgetting where you left your keys this morning.
Piracetam by Peak Nootropics
Two questions I get A LOT from people who are new to Biohacking and haven't yet tried smart drugs is: Which smart drug…
While non-prescription and very safe, Piracetam is a hardcore drug which has an invasive effect on the neurobiology. If you’re going to use it in the long term to upgrade your mind you’ll want to combine it with a few cofactors in a specific protocol, the Piracetam Protocol to maximize the cognitive bang for your buck.
There’s other smart drugs in the Racetam family that are certainly interesting and there’s a lot of ways to use them BUT Piracetam is probably the safest, cheapest and most consistently effective for the most people so it’s what you should start with. Order Piracetam
Piracetam - Peak Nootropics
Suggested Quantities: 1-3g Directions: Piracetam is water soluble. This product is sold as a chemical and any usage is…
Phenylpiracetam — This is a supercharged version of Piracetam. There’s three human clinical trials totalling nearly 500 human subjects that demonstrate a positive effect on cognitive decline.
Phenylpiracetam by Peak Nootropics
By Jonathan Roseland Connect This is a cognitive enhancer which actually made me really optimistically narcissistic…
Oxiracetam — The anti-aging properties of this Racetam have been demonstrated in five human clinical trials.
Oxiracetam by Pure Nootropics
I've been doing Oxiracetam for about 3 months now and it is becoming one of my favorite smart drugs because, for me at…
Cognitive decline has everything to do with Mitochondria, the little power plants of the cells. Dr. Lee Know explains in his book, The Future of Medicine
…compromised mitochondrial function is now seen as one of the leading causes of a wide range of seemingly unconnected degenerative diseases , and even the aging process itself .(1095–1096)
Alzheimer’s disease is the most common form of adult — onset dementia ; an eighty — year — old has about a 30 percent chance of developing Alzheimer’s . (1399–1400)
Based on the research I’ve done for this book, I would agree that the long-held beliefs about Alzheimer’s are falling apart and the most current research shows we need a greater focus on mitochondria in the prevention and treatment of the disease. (1409–1411)
I have here the Mitochondrial Nootropics that deliver the best ROI and credible sources to order them from.
Acetyl L-Carnitine (ALCAR) — Peak Nootropics
Recommended Dosage: 500–1000mg Directions: Acetyl L-Carnitine is water soluble. Recommended to take with food. Do not…
Listed in descending order of the most effective and most economical, if you have a limited budget get the ones near the top of the list
- Piracetam (Source)
- ALCAR (Source)
- CoQ10 (Source)
- Glutathione (Source)
- Magnesium (Source)
- Creatine (Source)
- Sulforaphane (Source)
- Methylene Blue (Source)
- Nicotine (Source)
- Grape Seed Extract (Source)
- Krill Oil (Source)
Ginkgo Biloba and Ginseng
This is probably the best nutraceutical combination for helping cognitive decline. A significant placebo controlled study of several hundred human subjects over 12 weeks, strongly suggested a quintessential cofactor relationship with Ginkgo Biloba, together they had an exponential effect on alertness, relaxation and appetite. From its abstract:
“It was concluded that despite the fact that healthy, employed subjects were evaluated, treatment with the combination of active substances had significant advantages over placebo therapy.”
Ginkgo Biloba and Ginseng is such a popular combination that you can probably find them at any pharmacy BUT when it comes to herbs sourcing really matters and there’s a qaulity spectrum. You don’t want to just get any herbs and certainly not the cheapest ones. You want to get herbs that are certified organic and ideally verifed as 97% pure with a certificate of analysis. Here’s some sources that meet my high standards
Maximum Strength Pure Organic Ginkgo Biloba Powder, 8 Ounce, Powerfully Promotes Focus, Memory &…
Buy Maximum Strength Pure Organic Ginkgo Biloba Powder, 8 Ounce, Powerfully Promotes Focus, Memory & Mental Performance…
Auragin Authentic Korean Red Ginseng - Made in Korea - 6 Year Roots - No Additives or Other…
Ginseng has been used as an herbal supplement for over 2000 years. It has been shown in clinical trials to increase…
There’s good evidence that 10–15 minutes of brain training daily with brain training software, especially the Dual N-Back app, can sharpen your mind and memory.
From a 2017 human clinical trial.
We studied 97 healthy older adults above the age of 65. Healthy older adults completed either an 8-week web-based cognitive training program on working memory or logic and planning. An additional no-training control group completed two assessments 8-weeks apart. Participants were assessed on cognitive measures of near and far transfer, including working memory, planning, reasoning, processing speed, verbal fluency, cognitive flexibility, and creativity. Participants improved on the trained tasks from the first day to last day of training.
Dual N-Back Pro
I've done brain training for 3 years now and this app is significantly more challenging than anything I've tried…
Dr. Mark Ashton Smith analyzed an 2018 article, Multi-modal fitness and cognitive training to enhance fluid intelligence, that appeared in the journal Intelligence:
The study was a comprehensive 4-month placebo controlled trial, with 424 healthy adults (age 18–43 years, 50% Caucasian), and the results are summarized in this figure:
Visual search training (simple perception exercises) saw a 4 point post-training IQ gain. Fitness training saw a 7 point IQ gain. Cognitive and fitness training (combined) saw a >9 point IQ gain.
The training gains were in visuospatial fluid intelligence. No groups improved in verbal IQ. This is an important finding, helping to explain some of the null results in previous studies.
Fluid intelligence includes such abilities as pattern recognition, abstract reasoning, and problem-solving.
The cognitive training in this study — also implemented in HighIQPro — takes a multi-modal approach — combining both dual n-back (working memory) training with executive control (attention) training.
So after 4 months exercise increases your IQ by 7 points, even more when combined with brain training.
According to Dr. Lee Know
It’s been known for decades that aerobic exercise can increase the number of mitochondria in your muscle cells by up to 50 percent in as little as six weeks . To get the benefit , however , you need to do aerobic exercises ( such as running , cycling , swimming , or walking briskly ) at an intensity that’s at least half of your maximum capacity . This intensity needs to be sustained for at least fifteen to twenty minutes per session , three to four times a week . (3014–3017)
So you want to do cardio to the point of sweating for 15 minutes a few times a week.
5 days a week, try to practice what the world’s leading anti-aging researchers and biohackers recommend enthusiastically, a daily fast of about 16 hours. Do all your eating and snacking within an 8 hour window; for most people this means eating a large, filling dinner around 9PM, going to bed, skipping breakfast and eating a substantial lunch with lots of healthy fats around 1 PM. This puts your body into a ketogenic state; burning fat instead of glutamate.
- At first, it may be excruciating to fast for 16 hours but quickly you get used to it and it doesn’t really bother you.
- Skipping breakfast and snacks ends of saving you quite a bit of time and money.
- Avoid eating carbs, sugar or bread especially when you’re fasting as your body will switch back over to glutamate.
- As long as you’re feeding your brain lots of the healthy fats it needs, you’ll have plenty of energy.
If you’re really a performance enhancement junkie you’ll want to consume some high quality MCTs while in a fasted state, many do this by starting their morning with a Bulletproof-style coffee mixed with butter and MCT oil.
But if you really want to experience all the cognitive and longevity benefits of Ketosis that you hear everyone online ranting and raving about you don’t want to consume just any old MCTs, you’re going to have to be very discriminating!
- You’re going to want to avoid the useless and harmful MCTs; lauric acid, C6 and C12.
- Be wary of impure MCT products, a certified organic stamp is not enough, ideally you want to see the manufacturer’s certificate of third party analysis with spectroscopy report evidencing above 97% purity, what’s considered pharmaceutical grade.
- Of course, you’ll want to avoid anything containing artificial sweeteners, coloring or weird chemicals with names you can’t pronounce!
Ultra Keto+MCT by Ultra Human meets my stringent standards, combining Patented Exogenous BHB Ketones and Pure C8 MCT along with selenium citrate, pink Himalayan salt and malic acid that gives it a delicious, non-artificially sweetened taste.
If you can’t afford to or are unable to get your hands on high-quality MCTs, try intermittent fasting anyway; it’s still a smart lifehack for health and productivity!
What I like about this morning ketosis cocktail is that these performance enhancers work on totally different neurobiological mechanisms than Racetams, Modafinil or other common smart drugs which is great news for long term Nootropics users who have built up a tolerance to cognitive enhancers that they have to take at increasing dosages for increasingly underwhelming results.
Ultra Keto + MCTs
Ratings, reviews and information (supplement pricing, facts, ingredients & side effects) about Ultra Keto + MCTs by…
Problematic Gene Alleles
Your genes have a lot to do with the cognitive decline that you may or may not face in the future. It’s worth it to get your personal genotyping done to see what chronic diseases you might be most susceptible too.
This article lists numerous problematic genes (which maybe lurking inside you!) predicting Alzheimer’s, Parkinson’s, Diabetes & other diseases.
130 Problematic Gene Alleles predicting Alzheimer's, Parkinson's, Diabetes & other diseases …
By Jonathan Roseland Connect Smart Nootropics in the UK. Spend £100 and receive a complimentary biohacking…
Head Strong by Dave Asprey — Your quality of life fundamentally relies on the health and proper functioning of your mitochondria; the base level energy generation system of the body. This book is chuck full of biohacks for living the bulletproof life.
The Memory Book — If you’ve noticed that your memory isn’t as sharp as it used to be you’ll want to consider using the memory systems in this short, fun, easy to read book.
The Memory Book: The Classic Guide to Improving Your Memory at Work, at School, and at Play
This short book will teach you memory systems to attain a savant-like memory faculty for acquiring new skill sets…
The Alzheimer’s Prevention Program by Dr Gary Small — Dr. Small has developed a holistic program for effective prevention.
The Alzheimer's Prevention Program: Keep Your Brain Healthy for the Rest of Your Life
The only "cure" for Alzheimer's is prevention, and The Alzheimer's Prevention Program shows the reader how to…
Perhaps all on your own you just don’t have the discipline to overcome cognitive decline. There’s all these motivational mechanism and tools but sometimes what totally outperforms all of them is just someone elses expectations of you. A lot of people ask their friends, family or significant other to be their accountability partner BUT there’s a lot of downsides to this — it introduces some tension and pressure to the relationship and robs harmony from the relationships that should be the most reinvigorating and comforting — many have ruined their marriages and friendships this way. I suggest coaching — hire a lifecoach or expert consultant — but this can be expensive and time consuming, which is why we offer a very lean biohacking consulting/life coaching program. Here’s how this would work…
- The Biohacking Consultation is 1 hour and 45 minutes total — which is actually two consulting calls.
- First Call 1 hour — Discovery & Strategizing call, I need to ask you some questions, we’ll discuss your history and outline a biohacking strategy and action plan to overcome your issues.
- Second Call 45 minutes — Follow up call in 30 or 60 days to see how you’re doing with the plan we outlined; how you’ve improved, what you’re struggling with, etc
There’s a few important reasons we split the time up into two calls
- It’s a significant motivation hack for you to follow through on the biohacking habits and plan we’ll outline because you’re accountable to me in 30 or 60 days.
- I’m incentivized to come up with a really effective biohacking strategy for you because I have to talk to you after you’ve been following it for a month or two.
- It timeboxes us with a deadline in 30 or 60 days for you to make improvements and accomplish your goals.
Your Skin in the game here is that you’re paying good money for this and you’re accountable to me on another call in 30 or 60 days. You’ll have to explain your lack of action if you fail to follow through.
My Skin in the game here is that I’ll offer a 60-day money back guarantee on this life coaching. If my coaching and action plan really fails you can have your money back. For this reason, I don’t accept everyone as a client.
PLEASE fill out this form
Take a few minutes to answer a few questions, if your issues are really far outside my areas of expertise I’ll decline the consultation. My time is finite and very valuable so I only want to spend it consulting the people I can really help. Thanks in advance for your understanding!
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