Cycloferon — An Interferon Hack
A Full-Spectrum Antiviral (and Remdesivir Alternative?)
Cycloferon is a notable immune-boosting medicine and interferon hack that’s come on my radar in the course of my research into COVID-19 treatments.
It’s a direct anti-viral that blocks the reproduction of the viral infection, and to this effect it’s fast-acting, its treatment course is between several days to a week, so you’ll know quickly if it’s working for you.
The pharmaceutical giant Gilead, which received about $70 million in taxpayer dollars will sell its COVID-19 drug Remdesivir for between $2000 — $4,460 per-treatment-course, so thousands of dollars for ten days worth of pills. The manufacturing cost for that standard Remdesivir course is shockingly low, $9-$10. That’s amazing right, the more I learn about big pharma, the more I wish that hell was a real place because some people really do deserve to go there. Because of the psychopathic greed of big pharma, we need to look to affordable alternatives like Cycloferon.
Fair price for Gilead's COVID-19 med remdesivir? $4,460, cost watchdog says
While Gilead has yet to present a marketing plan for remdesivir-much less a price-ICER figures the COVID-19 drug could…
It’s been widely studied since the turn of the millennia, over 160 published scientific papers can be found on Pubmed along with 52 human clinical trials, this is a substantial amount of science for us to delve into.
"Cycloferon"[Title/Abstract] - Search Results - PubMed
"Cycloferon"[Title/Abstract] - Search Results - PubMed
"Cycloferon"[Title/Abstract] - Search Results - PubMedpubmed.ncbi.nlm.nih.gov
Prevents and Treats Influenza
A multi-center Russian trial was done with over 500 Influenza and Acute Respiratory Tract Viral Infection patients, the Cycloferon treatment was highly effective, those who received it had approximately 10% occurrence of infection compared with those who did not receive it.
The complicated forms of the disease were recorded in 1.5% of the patients treated with cycloferon and in 10.5 and 11.3% of the patients not treated with cycloferon.
Клиническая эффективность иммуномодулятора циклоферона (таблетки) при вирусных инфекциях органов…
The authors carried out a systematic review and subsequent meta-analysis of randomized clinical trials evaluating the…
From a 2017 meta-analysis and systematic review, Clinical efficacy of the immunomodulatory agent cycloferon (tablets) in viral respiratory infections
Thus, the use of cycloferon to treat and prevent acute viral respiratory infections showed a more than 5-fold increase in the probability of avoiding the disease or enduring the latter in a mild form.
Several of the trials combined it with other drugs and therapies…
- A 2012 trial totaling 238 patients with Widespread Forms of Pulmonary Tuberculosis. noted an uptick in successful outcomes of treatment.
- A mammoth 2015 study of over 6000 patients with Advanced Pulmonary Tuberculosis concurred and concluded: The effect of Cycloferon in such cases was likely due to both its direct immunoprotective action and the improvement of the general state of the patients and their higher adherence to the treatment. I’ll point out that the patients stuck with the Cycloferon treatment, making it more effective, this speaks to the general safety and tolerability of the medicine. Many Tuberculosis drugs are very unpleasant, and patients have problems staying on them, this is where Cycloferon stands out.
- 100 Patients with manifest HPV infection received Cycloferon in 2010 trial, noted that it is well tolerated, is not painful, and increased the effectiveness of an immunophysiotherapy course of treatment to empower the immune system to suppress the nasty infection.
- While it’s not a Nootropic, a 2015 trial asserts that it can be used in combination with the drug Reamberin® to treat recurrent depressive disorders.
Dosage and Usage
Take the entire dose together once daily, no need to split up doses, take it on an empty stomach with water about 30 minutes before a meal.
- 4 tablets (600 mg) daily is the recommended dose for treating flu and acute respiratory infections that you would want to take for 7 days and then take a break.
- To treat severe influenza, take 6 tablets (900 mg) on the first day and 4 tablets (600 mg) on subsequent days.
Acute Respiratory Viral Infection (ARVI) Treatment
The Results of Multicenter Randomized Trials published in 2019, notes a 2.9–7.2-fold decrease of the morbidity and that…
The marked cytoprotective effect, evident from lower destruction of the epithelial cells and increased activity of the local nonspecific resistance factors (lysozyme, secretory immunoglobulin A) was observed.
[Improvement of Natural Resistance in Children for Prophylaxis of Influenza and Acute Respiratory…
The results of the multicentre clinical trials on cycloferon efficacy in children at the age from 4 to 16 years are…
Interferons are a crucial immune system component. A 2012 clinical trial gave the drug to 35 healthy volunteers to evaluate its effect on Interferon production…
It is established that cycloferon induces the production of early alpha-IFN within [24 hours] from the moment of drug introduction.
[Dose-dependent Interferon-Induction Activity and Pharmacokinetics of Cycloferon in Healthy Humans]…
Dose-dependent interferonogenic activity and pharmacokinetics of cycloferon--a low-molecular inductor of…
Prevention of COVID-19 and SARS
The most recent piece of scientific literature published was a 2019 Russian Meta-Analysis, which analyzed over 500 papers evaluating and comparing Cycloferon with other Upper Respiratory Tract Infection treatments. The two takeaways from this were
- It added 25% to absolute and relative usefulness of medical intervention.
- Increased the chances of recovery from infection by 3.5 times.
[Cycloferon Efficacy in Treatment of Upper Respiratory Tract Infections: Systematic Review and…
Medical scientific sources about randomized clinical trials of Cycloferon were studied as a single plot of 531…
In early 2020, Cycloferon’s manufacturer Polysan donated the medicine to fight COVID-19 in the Philippines.
Russian pharma company offers to donate free medicine for treatment of COVID-19 in PH
Metro Manila (CNN Philippines, March 12) - A leading Russian pharmaceutical company is ready to donate medicine for the…
I did search the internet for anecdotal accounts of Cycloferon treatment and didn’t turn up much on English-language forums or Reddit, but I did come across some interesting #Cycloferon Tweets.
Risk Grade: B+
The most recent human study done was a safety evaluation of the drug, it found that just 2.5% of fever patients given it experienced negative side effects and…
All of them were mild and did not require discontinuation of the drugs use.
[Evaluation of Safety and Pharmacotherapeutic Efficacy of Cycloferon in Treatment of Astrakhan…
Clinicopathogenetic impact of cycloferon, an endogenous interferon inductor, on the process of Astrakhan rikettsial…
In several clinical trials, it was administered to children and, with an absence of notable adverse side effects, it can be considered safe for children. From a Cycloferon efficacy study:
A study on the effects of Cycloferon on the body showed that the drug does not adversely affect vital organs, in particular the liver, because it is not metabolized in it. It does not stay in the body and is excreted by the kidneys unchanged within a day after administration
[Cycloferon Efficacy in the Treatment of Acute Respiratory Tract Viral Infection and Influenza…
Clinical signs of acute respiratory tract viral infection and influenza in 150 patients under the standard symptomatic…
As far as Coronavirus biohacks go, Cycloferon is a pretty good value.
A couple of the clinical trials pointed out that it’s modern, cost-effective medicine.
The study showed a high clinical and cost-effectiveness of [Cycloferon] compared to traditional [methods], that allows to recommend it for the provision of specialized medical care in the treatment of patients with infectious and complicated gunshot fractures…
Concluded a Russian study done at a hospital in Yemen, where they used it battle infections resulting from gunshot wounds. Hopefully, you’re not going to get COVID-19 (or shot) anytime soon but…
“It’s not just you. Things are getting crazier out there…” to paraphrase the 2019 film, Joker
Considering its wide-spectrum anti-viral effects, safety, and affordability it’s a medicine that deserves a place in the antifragile biohacker’s prepping warchest.
A 20 tablet (150 mg/tab) Cycloferon package is just 15 euros from RUPharma.