Lion’s Mane — The Best Nootropic Mushroom

A Nootropic mushroom for risk-averse biohackers with a wide range of cognition-enhancing effects.

Scientific Research

In the notable 6-month, double-blind placebo-controlled human study done on Lion’s Mane the dosage administered was 3 grams daily. You would have to do about 8 capsules daily of Neuro-Stack to get that much, although the study was done on cognitively impaired middle-aged and elderly Japanese patients. You probably need a whole lot less of the stuff. In the human research, there are several remarkable effects of Lion’s Mane…

History and Origin

Found primarily in North America, Europe, and East Asia, the Lion’s Mane mushroom has a long history of being used in traditional medical practices. The ancient Chinese referred to mushrooms as the “spirit plant” as they believed mushrooms to be a source of longevity and spiritual wisdom. The ancient Chinese used the Lion’s Mane mushroom for a variety of digestive ailments, long before modern medicine came onto the scene.

Neuroprotective Properties

Alzheimer’s and Dementia are terrible illnesses that not only affect the sufferer but also their families and friends. One of the biggest draws of Lion’s Mane is its neuroprotective properties. Lion’s mane mushroom can be used to help protect against the onset of dementia. In other words, it has the potential to help retain mental functions such as memory and general cognition. These mushrooms contain two compounds, called hericenones and erinacines, that are known to help stimulate brain cell growth. In animal studies, it has also shown the potential to help with serious neurodegenerative diseases such as dementia and Alzheimer’s disease.

Depression and Anxiety

Mental health conditions like depression and anxiety can make it significantly more difficult to function in everyday life. Lion’s mane has been studied in mice for its ability to improve mood. Some studies have shown that Lion’s Mane mushroom can improve the functioning of the hippocampus, because of its ability to stimulate brain cell growth.

Treating Ulcers

Stomach ulcers are sores that can form anywhere in the digestive system. The most common causes of these ulcers are the overgrowth of bacteria in the gut, and damage to the stomach from daily use of NSAIDs like aspirin.

Reduction of Heart Disease Risk

Heart disease is a leading cause of death in the United States and elsewhere. Some causes of this condition are high cholesterol, obesity, and a sedentary lifestyle. If dietary and exercise changes are not enough, adding Lion’s Mane mushroom might be worth adding to your regimen with the advice of a doctor.

Weight and Diabetes Management

Diabetes can be a very difficult illness to manage, especially for those that lead busy lives and have little time to deal with their blood sugar. Lion’s mane mushroom can be added to a treatment regimen to make managing this condition a little easier.

Nervous System Injuries

The nervous system is comprised of the brain, spinal cord, and the network of nerves that span the body. Injuries to the central nervous system are serious and require significant treatment to protect your quality of life. These injuries can be incapacitating, leading to paralysis or even death.

Immune System Booster

The immune system is our first line of defense against all of the things in the world that can get you sick. If your immune system is compromised, due to illness or poor health, you are much more likely to get sick. For those who are immunocompromised, getting sick with a mild cold can end up being a significant event with serious consequences.


When looking to try a new supplement, it can be helpful to read some testimonials from people who have taken it themselves. A simple internet search can reveal a plethora of posts from people who have taken Lion’s Mane for one condition or another. Most of these people have reported few or no side effects from taking Lion’s Mane mushroom.

Hot Water Extracted

This is the optimal extraction method for the bioavailability of Lion’s Mane’s constituent parts.


Lost Empire Herbs in the USA offers Organic Dual Extracted Lion’s Mane powdered at an 8:1 proportion.

Watch: A Neurogenesis Unleashing Nootropic Mushroom [Lion’s Mane Biohacker Review]

The Lion’s Mane in Neuro-Stack is 100% mushroom fruiting body.

Order: NEURO-STACK — Brain Support Supplement — 27 Nootropics with Absorption Enhancers, Nootropic Stack, Brain Booster, Focus, Anxiety Relief, Vegan, Organic Lion’s Mane Mushroom Capsules, Turmeric Curcumin, Bioperine
Double-check that the heavy metals fall within acceptable toxicity ranges

Usage & Dosage

In the clinical studies, the dosage used was three doses daily of 1000 milligrams (3000 milligrams total)

Side Effects

Generally, Lion’s Mane is a non-toxic substance and, as we’ve covered here, is safe to take. As such, there are very few side effects that users need to worry about. A 2016 study looked at the effects of Lion’s Mane mushrooms on rats and found that no side effects presented themselves, even at high doses. They stated:

Risk Grade: B+

  • It’s a natural, non-toxic mushroom not some sort of exotic, molecule created in a laboratory or a pharmaceutical factory.
  • It’s been the subject of several human clinical trials totaling 60 participants, one which lasted 4 weeks and the other 6 months.
  • A 90-day animal study noted no adverse effects.
  • It would be nice to see some population studies or long-term studies with follow-up after years of usage.
  • There was one case of an elderly man who was hospitalized for acute respiratory failure. Apparently, the guy had excess lymphocytes which negatively reacted to the Lion’s Mane extract he had been using for 4 months.
  • Pure organic, Lion’s Mane grown on natural substrates probably deserves an A+ grade but a lot of the Lion’s Mane out there is of lower quality. The fruiting bodies of mushrooms attract a lot of toxins from their environments via Mycoremediation which is why you only want Lion’s Mane that comes from a pristine source.

Mysterious Mushrooms

Originally published on I’m not a doctor, medical professional, or trained therapist. I’m a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinking. You should consult a professional about any serious decisions that you might make about your health.

Adventuring philosopher, Pompous pontificator, Writer, K-Selected Biohacker, Tantric husband, Raconteur & Smart Drug Dealer 🇺🇸