N-Acetyl Cysteine: a Biohack for those who have succumbed to Vice

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N-Acetyl Cysteine is a slightly modified version of the sulfur-containing amino acid cysteine. It is especially useful to those who have succumbed to vice but as a general Biohack, its effect on glutathione is most interesting.

Scientific Research

The sad consequence is that most aging individuals have never heard of it. Even many doctors remain unaware of its potential role as a frontline defense against some of today’s most deadly public health threats…

Glutathione Hack

“Breathing is bad for us”


Is NAC a Nootropic?

  • Prevent glutamic toxicity
  • Boosts dopamine
  • Reduces inflammation
  • Free radical damage
  • NAC influences the amounts of dopamine in the brain
Solgar — NAC 600 mg, 120 Vegetable Capsules
  • No notable studies mentioned an effect on cognition or memory.
  • In the anecdotal cases where Nootropic effects are reported it seems that it is treating neurological deficits. I don’t think it’s a performance enhancer.

Vs Flu and the Common Cold

Vs Autism

Vs Diabetes

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial

Vs Cocaine Addiction

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Vs Smoking Addiction

  • This study recorded participant ratings of use and cravings as well as biochemical measures to confirm reported use.
  • In addition to the modulation of glutamate to reduce cravings and reward behaviors, NAC may have a role as an antioxidant in a disorder where oxidative stress is marked.
  • There were no significant difference in the number of cigarettes smoked or carbon monoxide levels between the NAC and placebo groups.
  • Treatment adherence and side effects were not reported.
  • The authors noted that alcohol was a significant covariate, and after the removal of 2 outliers based on alcohol consumption and resulting nicotine use, there was only a post hoc trend toward a decreased number of cigarettes smoked in the NAC group, and this did not correspond with decreased carbon monoxide levels.
  • Owing to the exclusion of participants from the analysis and the variability of the sample in terms of extraneous factors such as alcohol use, the sample size of this study was too small to make definitive conclusions.
  • The outcome of the study was to assess the effects of NAC on the detrimental biophysical aspects of smoking. Participants were randomly assigned to placebo or NAC (1200 milligram daily) groups and treated for 6 months.
  • The study found that in the NAC group, there were decreases in lipophilic DNA adducts between baseline and endpoint.
  • Participants provided weekly ratings of withdrawal symptoms, cravings, and carbon monoxide (CO) measurements and logged daily cigarette and alcohol use.
  • The results indicated that the cystine-glutamate exchanger and the glial glutamate transporter were downregulated after nicotine self-administration, and augmenting exchanger activity with NAC reduced the number of cigarettes smoked in nicotine-dependent individuals.

For Cannabis Quitters

Alcohol use during a trial of N-acetylcysteine for adolescent marijuana cessation

Hangover Biohack



Downloadable NAC?

Access NAC infoceutical

Vs Activated Charcoal

Order Bulletproof, Charcoal Coconut 500 Mg, 90 Count




  • The patients were divided randomly into 2 groups. Those in the study group (60 men) were given NAC (600 mg/d orally) for 3 months; the control group (60 men) received a placebo.
  • The results demonstrated that NAC had significant improvements in the volume, motility, and viscosity of semen.

Side Effects

  • Very rarely it can cause nausea, vomiting, diarrhea, and constipation.
  • Even more rare drowsiness, rashes, low blood pressure, and liver problems.


Risk Grade: B

  • The significant body of scientific investigation has failed to identify any concerning undesirable effects.
  • The incidence of negative side effects was tiny compared to glowing reports of benefits.
  • Not recommended for people who have a genetic condition called cystinuria.
  • The main concern with NAC, as with many popular supplements, is the purity of the actual supplements.


Capsuled or Powdered Pharma Grade NAC

Should otherwise healthy people (or Biohackers) supplement NAC?

  • NAC as a supplement has many uses and can help people with a diverse set of issues, including mental health disorders like OCD, Autism, PTSD, etc, addiction issues, infections, inflammations, and states of oxidative stress.
  • It boosts the production of glutathione and plays a role in the detoxification of heavy metals out of the body.
  • NAC is commonly used for liver support but people often take it to treat bronchitis, relieve hangover symptoms, increase immunity against certain strains of flu, improve insulin resistance and thereby help improve diabetes, and hypoglycemia.
Originally published on LimitlessMindset.com. I’m not a doctor, medical professional, or trained therapist. I’m a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinking. You should consult a professional about any serious decisions that you might make about your health. Affiliate links in this article support Limitless Mindset — spend over $100 and you’ll be eligible to join the Limitless Mindset Secret Society.



Adventuring philosopher, Pompous pontificator, Writer, K-Selected Biohacker, Tantric husband, Raconteur & Smart Drug Dealer 🇺🇸

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Jonathan Roseland

Adventuring philosopher, Pompous pontificator, Writer, K-Selected Biohacker, Tantric husband, Raconteur & Smart Drug Dealer 🇺🇸