Phosphatidylserine a Stress Defeating Agent for a High Performance Memory

This amino acid is a potent combatant of stress, which lowers cortisol while at the same time supporting cognitive function and aiding memory.

Scientific Research

Over 45 human clinical trials have been published on it in scientific journals.

Vs Stress

It decreases perceived exertion and cortisol from exercise or stress.

Performance vs Stress

In this and other studies, the human participants were subjected to various social and task-related performance demands in the testing environment. The interesting finding was that despite higher performance the stress levels of the participants did not increase proportionally.

The Golfer’s Nootropic

Interestingly one of the landmark human trials on phosphatidylserine focused on Golfers, apparently, the stress-reducing action resulted in a better golf game. To quote a study which appeared in 2007 in the Journal of the International Society of Sports Nutrition.

Cognitive Enhancer

A 2011 American double-blind study done on athletes showed that supplementation of 400 Milligrams of the amino acid was a positive influence on cognition without influencing mood:

  • Improved accuracy (39% less wrong answers, 13% more right answers)
  • Quantitative analysis
  • Day trading
  • Financial analysis
  • Architectural design
  • Accounting
  • Programming


A 2013 Japanese double-blind, placebo-controlled study of 36 children demonstrated that 2 months of supplementation improved global symptoms of ADHD, auditory memory and impulsiveness.
Which means it decreased the ‘distractibility’ of children in the classroom, improved their retention and ability to repeat what was being taught and decreased incidences of children acting impulsively. The bottom line is that parents with little monsters should consider 60 days of Phosphatidylserine before putting their children on amphetamine solutions like Ritalin or Adderall.

Vs Cognitive Decline

Phosphatidylserine concentrations in the brain decline with age. There have been five double-blind human studies demonstrating that Phosphatidylserine supplementation is between mildly helpful and completely transformational for those suffering from Alzheimer’s and Dementia.

Memory Enhancement

It’s been demonstrated in 3 human studies to augment general memory and working memory in another double-blind study. To quote another Japanese study:


Like many other Nootropics that come from the natural world, seafood, particularly herring and mackerel are good sources of Phosphatidylserine. A more dubious source is sunflower oil.

Recommended Daily


A significant amount of data from the human studies suggest that concurrent Omega-3 Fish oil and Krill Oil supplementation is very important to maximize the Biohacking value from Phosphatidylserine.

Side Effects

Supplementing +300 Milligrams may result in stomach upset or insomnia. There are some concerns with the transmission of mad cow disease because some Phosphatidylserine is derived from Bovine cortexes. However, there are virtually no documented cases of this happening according to

Nootropic Stacks?

Phosphatidylserine PS-100 Capsules
  • The Phosphatidylserine is not verified as a pharmaceutical grade by analysis or spectroscopy.
  • You cannot experiment with raising or lowering the dosage specifically.

When to Expect Results…

What I’m hearing consistently from the scientific sources is that Phosphatidylserine supplementation begins making an impact at between 30–90 days. So not a Nootropic to expect instant results from!

Adventuring philosopher, Pompous pontificator, Writer, K-Selected Biohacker, Tantric husband, Raconteur & Smart Drug Dealer 🇺🇸