Pramiracetam: The Rich Man’s Memory Enhancement Drug

Watch Pramiracetam as a Nootropic: Benefits, Sources, Dosage, Side effects, and Supplements

A 2004 research study suggested that Pramiracetam could be five to ten times stronger than normal Piracetam.

This article is mostly going to focus on decoding what the human studies are saying about Pramiracetam and how this squares up with the anecdotal experiences of Biohackers online. For more of my own personal experiences, thoughts, and comparisons please see the written and video reviews in the sidebar.

Scientific Research

Scientific studies and papers have demonstrated and documented that Pramiracetam can both be used to treat neurodegenerative conditions in the elderly or give an edge to those who already have high functioning memories.

You can find 40 different studies done specifically on Pramiracetam on Pubmed in addition to hundreds of more studies on the Racetam family of drugs.

Long Term Memory

As a smart drug the primary reason to take Pramiracetam is to boost long term memory and learning efficiency, in particular, it is effective at increasing spatial memory. This is because Pramiracetam boosts activity in the hippocampus by supercharging acetylcholine synthesis with its affinity to the choline uptake process. Acetylcholine is most commonly thought of as the neurotransmitter that facilitates the formation of new memories and as a chemical messenger in the nervous system of the body.

Powdered Pharma Grade Pramiracetam

Speaking of memory, an Italian study of 35 elderly people demonstrated that Pramiracetam supplementation over 12 weeks was more effective for memory loss than weekly memory training sessions of 90 minutes done with tutors.

It has been demonstrated to improve long term memory but holds no advantage to the ‘working memory’ — the RAM of the mind which solves problems and deals with novel situations. Another great reason for Biohackers to consider cross-training Dual N-Back with taking Pramiracetam.

A Longecity user eloquently describes its effects on memory:

“I know exactly what you mean with the random recall. It’s beautiful actually. I realize my past with such vivid perfection, not necessarily nostalgic, but more like looking at a beautiful frozen creek in the middle of winter with snow falling around you and your beautiful lover next to you. Not an aroused feeling, but more serene and spiritual. If the racetams have done anything important, they have heightened my aesthetic ability.”

Spatial Memory

This makes Pramiracetam as a smart drug an excellent choice for professionals whose skill sets require a robust spatial memory such as:

  • Architects
  • Engineers
  • Graphic designers
  • Website designers
  • Artists

Those who rely heavily on their spatial memory should consider combining the smart drug with Dual N-Back brain training regimen, which increases spatial memory consistently within 20 training sessions.

Mechanism of Action

Part of Pramiracetam’s mechanism of action is increasing blood flow to the brain; which makes you more energetic, focused and attentive but you shouldn’t drink alcohol on it.

Cognition Enhancer

A quick Google search demonstrates that Pramiracetam lives up to its title as a cognitive enhancer

“I have had 5 grams so far. I feel an unprecedented surge of creativity, insight, philosophical reasoning, and articulation.”


Pramiracetam is a case of study of the success of the patent system. It was originally developed and patented by Parke-Davis (now a subsidiary of Pfizer) in 1979. It has been studied exhaustively worldwide both in human and animal studies.

Signal Enhancer

A Swiss study demonstrated that Pramiracetam aids memory in the way it optimizes the adrenals. To quote the study referring to Racetams:

Their unique feature is that they exert distinct effects on memory, but show hardly any biochemical activity and are practically devoid of toxic effects.

A German study indicated that Pramiracetam facilitates better cell to cell signaling:

…some of the pharmacological properties of piracetam can be explained by its effects on membrane fluidity.

The Red Pill Formula for Cognitive Capital

Watch The Red Pill Formula for Biohacking Cognitive Capital

Pramiracetam is such an expensive and rare smart drug that you rarely see it included in the consumer-grade Nootropic stack products. However, pharmaceutical grade Pramiracetam is an ingredient in Caballo, the red pill formula for cognitive capital.

Professor Jerry Muller, the author of The Mind and the Market, articulated it best:

“…a period of growing equality of access to education and increasing stratification of marketplace rewards, both of which have increased the importance of human capital. One element of human capital is cognitive ability: quickness of mind, the ability to infer and apply patterns drawn from experience, and the ability to deal with mental complexity. Another is character and social skills: self-discipline, persistence, responsibility. And a third is actual knowledge. All of these are becoming increasingly crucial for success in the post-industrial marketplace.” (March 2013, Foreign Affairs)

The extinction of jobs comprised of rote, repetitive and unsophisticated tasks is a dire inevitability thanks to the aggressive innovation that our economy fundamentally relies on. In the past, those of low or average intelligence were practically guaranteed an unremarkable life of labor in a factory or a field, fast forward to the very near future and nothing is guaranteed. The only hope is to stay well ahead of the curve of automation. It’s time to invest in your own cognitive capital.

Recommended Daily

1200 Milligrams daily (Split up into multiple doses)


Taking an acetylcholine precursor with Pramiracetam is a great idea because of it’s affinity to the choline uptake process, this means supplementing Alpha GPC or CDP-Choline. High amounts of any Racetam may lead to temporary ACh receptor “burn out” without an acetylcholine precursor present.

It does not affect the feel-goods Dopamine, Serotonin, and GABA. So if the objectives of your Nootropics habit include being more social and confident or overcoming anxiety or depression consider taking it with Piracetam or another Nootropic ingredient that boosts these other neurotransmitters such as L-Tyrosine, Theanine, Rhodiola or Vitamin B6.

Side Effects:

Pramiracetam, like other racetams, is very well-tolerated by humans. At unreasonably high dosages the worst symptoms reported are sleepiness, headaches, dizziness and lack of appetite.

Originally published on



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Jonathan Roseland

Jonathan Roseland

Adventuring philosopher, Pompous pontificator, Writer, K-Selected Biohacker, Tantric husband, Raconteur & Smart Drug Dealer 🇺🇸